Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.
Fretts, Amanda M
Murphy, Rachel A
Qureshi, Waqas T
Harris, Tamara B
Steffen, Lyn M
Yu, Chaoyu Ian
Steffen, Brian T
Tsai, Michael Y
Lemaitre, Rozenn N
The American journal of clinical nutrition
Oxford University Press
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Fretts, A. M., Imamura, F., Marklund, M., Micha, R., Wu, J. H., Murphy, R. A., Chien, K., et al. (2019). Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.. The American journal of clinical nutrition, 109 (4), 1216-1223. https://doi.org/10.1093/ajcn/nqz005
Abstract Background: Saturated fatty acids of different chain-length have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating levels of very-long chain saturated fatty acids (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Design: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium (FORCE) participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results: There were 14,276 cases of incident diabetes across participating studies. Higher circulating levels of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the relative risk (95% confidence interval (CI)) for incident diabetes was 0.78 (95% CI, 0.70, 0.87) comparing the 90th percentile to the 10th percentile of 20:0, 0.84 (95% CI, 0.77, 0.91) for 22:0, and 0.75 (95% CI, 0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher levels of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
InterAct Consortium, Humans, Diabetes Mellitus, Type 2, Fatty Acids, Eicosanoic Acids, Prospective Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male
NJW, NGF, and FI were funded by MRC Epidemiology Unit (MC_UU_12015/1, MC_UU_12015/5); NGF, AK, NJW, funded by National Institute for Health Research Biomedical Research Centre Cambridge (IS-BRC-1215-20014); and AK, funded by MRC Elsie Widdowson Laboratory MC_UD99999906 and Cambridge Lipidomics Biomarker Research Initiative G0800783.
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
European Commision (37197)
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
External DOI: https://doi.org/10.1093/ajcn/nqz005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288703