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dc.contributor.authorFretts, Amanda Men
dc.contributor.authorImamura, Fumiakien
dc.contributor.authorMarklund, Mattien
dc.contributor.authorMicha, Renataen
dc.contributor.authorWu, Jason HYen
dc.contributor.authorMurphy, Rachel Aen
dc.contributor.authorChien, Kuo-Liongen
dc.contributor.authorMcKnight, Barbaraen
dc.contributor.authorTintle, Nathanen
dc.contributor.authorForouhi, Nitaen
dc.contributor.authorQureshi, Waqas Ten
dc.contributor.authorVirtanen, Jyrki Ken
dc.contributor.authorWong, Kerryen
dc.contributor.authorWood, Alexis Cen
dc.contributor.authorLankinen, Mariaen
dc.contributor.authorRajaobelina, Kalinaen
dc.contributor.authorHarris, Tamara Ben
dc.contributor.authorDjoussé, Lucen
dc.contributor.authorHarris, Billen
dc.contributor.authorWareham, Nicholasen
dc.contributor.authorSteffen, Lyn Men
dc.contributor.authorLaakso, Markkuen
dc.contributor.authorVeenstra, Jennaen
dc.contributor.authorSamieri, Céciliaen
dc.contributor.authorBrouwer, Ingeborg Aen
dc.contributor.authorYu, Chaoyu Ianen
dc.contributor.authorKoulman, Alberten
dc.contributor.authorSteffen, Brian Ten
dc.contributor.authorHelmer, Catherineen
dc.contributor.authorSotoodehnia, Nonaen
dc.contributor.authorSiscovick, Daviden
dc.contributor.authorGudnason, Vilmunduren
dc.contributor.authorInterAct Consortium,en
dc.contributor.authorWagenknecht, Lynneen
dc.contributor.authorVoutilainen, Sarien
dc.contributor.authorTsai, Michael Yen
dc.contributor.authorUusitupa, Mattien
dc.contributor.authorKalsbeek, Anyaen
dc.contributor.authorBerr, Claudineen
dc.contributor.authorMozaffarian, Dariushen
dc.contributor.authorLemaitre, Rozenn Nen
dc.date.accessioned2019-02-02T00:30:49Z
dc.date.available2019-02-02T00:30:49Z
dc.date.issued2019-04en
dc.identifier.issn0002-9165
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288703
dc.description.abstractAbstract Background: Saturated fatty acids of different chain-length have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating levels of very-long chain saturated fatty acids (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Design: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium (FORCE) participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results: There were 14,276 cases of incident diabetes across participating studies. Higher circulating levels of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the relative risk (95% confidence interval (CI)) for incident diabetes was 0.78 (95% CI, 0.70, 0.87) comparing the 90th percentile to the 10th percentile of 20:0, 0.84 (95% CI, 0.77, 0.91) for 22:0, and 0.75 (95% CI, 0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher levels of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
dc.description.sponsorshipNJW, NGF, and FI were funded by MRC Epidemiology Unit (MC_UU_12015/1, MC_UU_12015/5); NGF, AK, NJW, funded by National Institute for Health Research Biomedical Research Centre Cambridge (IS-BRC-1215-20014); and AK, funded by MRC Elsie Widdowson Laboratory MC_UD99999906 and Cambridge Lipidomics Biomarker Research Initiative G0800783.
dc.format.mediumPrinten
dc.languageengen
dc.publisherOxford University Press
dc.subjectInterAct Consortiumen
dc.subjectHumansen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectFatty Acidsen
dc.subjectEicosanoic Acidsen
dc.subjectProspective Studiesen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.titleAssociations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.en
dc.typeArticle
prism.endingPage1223
prism.issueIdentifier4en
prism.publicationDate2019en
prism.publicationNameThe American journal of clinical nutritionen
prism.startingPage1216
prism.volume109en
dc.identifier.doi10.17863/CAM.35964
dcterms.dateAccepted2019-01-07en
rioxxterms.versionofrecord10.1093/ajcn/nqz005en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-04en
dc.contributor.orcidImamura, Fumiaki [0000-0002-6841-8396]
dc.contributor.orcidMarklund, Matti [0000-0002-3320-796X]
dc.contributor.orcidWu, Jason HY [0000-0003-2073-3562]
dc.contributor.orcidChien, Kuo-Liong [0000-0003-4979-8351]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidVirtanen, Jyrki K [0000-0002-0648-999X]
dc.contributor.orcidWood, Alexis C [0000-0001-7616-2119]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidSamieri, Cécilia [0000-0001-9809-7506]
dc.contributor.orcidBrouwer, Ingeborg A [0000-0002-8762-382X]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidGudnason, Vilmundur [0000-0001-5696-0084]
dc.contributor.orcidBerr, Claudine [0000-0001-5254-7655]
dc.identifier.eissn1938-3207
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/5)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMRC (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idEuropean Commision (37197)
pubs.funder-project-idBBSRC (BB/M027252/2)
pubs.funder-project-idBBSRC (BB/P028195/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M027252/1)
cam.orpheus.successThu Jan 30 10:51:45 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-30


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