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The mammalian mitochondrial epitranscriptome.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Rebelo-Guiomar, Pedro 
Powell, Christopher A 
Van Haute, Lindsey 

Abstract

Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression. Here we review the current knowledge on how the mammalian mitochondrial epitranscriptome participates in regulating mitochondrial homeostasis. In particular, we focus on the latest breakthroughs made towards understanding the roles of the modified nucleotides in mitochondrially-encoded ribosomal and transfer RNAs, the enzymes responsible for introducing these modifications and on recent transcriptome-wide studies reporting modifications to mitochondrial messenger RNAs. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Matthias Soller and Dr. Rupert Fray.

Description

Keywords

Animals, DNA, Mitochondrial, Epigenesis, Genetic, Humans, RNA Processing, Post-Transcriptional, Transcriptome

Journal Title

Biochim Biophys Acta Gene Regul Mech

Conference Name

Journal ISSN

1874-9399
1876-4320

Volume Title

1862

Publisher

Elsevier BV
Sponsorship
Medical Research Council (MC_UU_00015/4)
Medical Research Council (MC_UU_00015/7)