General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.
Schiöth, Helgi B
Frontiers in neural circuits
Frontiers Media SA
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Svensson, E., Apergis-Schoute, J., Burnstock, G., Nusbaum, M. P., Parker, D., & Schiöth, H. B. (2018). General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.. Frontiers in neural circuits, 12 117. https://doi.org/10.3389/fncir.2018.00117
It is now accepted that neurons contain and release multiple transmitter substances. However, we still have only limited insight into the regulation and functional effects of this co-transmission. Given that there are 200 or more neurotransmitters, the chemical complexity of the nervous system is daunting. This is made more-so by the fact that their interacting effects can generate diverse non-linear and novel consequences. The relatively poor history of pharmacological approaches likely reflects the fact that manipulating a transmitter system will not necessarily mimic its roles within the normal chemical environment of the nervous system (e.g., when it acts in parallel with co-transmitters). In this article, co-transmission is discussed in a range of systems [from invertebrate and lower vertebrate models, up to the mammalian peripheral and central nervous system (CNS)] to highlight approaches used, degree of understanding, and open questions and future directions. Finally, we offer some outlines of what we consider to be the general principles of co-transmission, as well as what we think are the most pressing general aspects that need to be addressed to move forward in our understanding of co-transmission.
Central Nervous System, Neurons, Synapses, Animals, Humans, Neurotransmitter Agents, Synaptic Transmission, Neuronal Plasticity
External DOI: https://doi.org/10.3389/fncir.2018.00117
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289062
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/