Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.
Waman, Vaishali P
Bannerman, Bridget P
Emerging microbes & infections
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Waman, V. P., Vedithi, S., Thomas, S., Bannerman, B. P., Munir, A., Skwark, M., Malhotra, S., & et al. (2019). Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.. Emerging microbes & infections, 8 (1), 109-118. https://doi.org/10.1080/22221751.2018.1561158
Of the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium tuberculosis (causative agent of tuberculosis), Mycobacterium leprae (causative agent of leprosy) and Mycobacterium abscessus (causative agent of chronic pulmonary infections) pose concern to global public health. Although antibiotics have been successfully developed to combat each of these, the emergence of drug-resistant strains is an increasing challenge for treatment and drug discovery. Here we describe the impact of the rapid expansion of genome sequencing and genome/pathway annotations that have greatly improved the progress of structure-guided drug discovery. We focus on the applications of comparative genomics, metabolomics, evolutionary bioinformatics and structural proteomics to identify potential drug targets. The opportunities and challenges for the design of drugs for <i>M. tuberculosis</i>, <i>M. leprae</i> and <i>M. abscessus</i> to combat resistance are discussed.
Animals, Humans, Mycobacterium, Mycobacterium leprae, Mycobacterium tuberculosis, Bacterial Proteins, Sequence Analysis, DNA, Proteomics, Computational Biology, Drug Resistance, Bacterial, Protein Conformation, Genome, Bacterial, Drug Discovery, Molecular Sequence Annotation, Mycobacterium abscessus
Medical Research Council (MR/N501864/1)
American Leprosy Missions (unknown)
Cystic Fibrosis Trust (SRC 010)
Fondation Botnar (Project 603)
External DOI: https://doi.org/10.1080/22221751.2018.1561158
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289558
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/