First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Tran, Maxine
Latifoltojar, Arash
Neves, Joana B
Papoutsaki, Marianthi-Vasiliki
Gong, Fiona
Abstract
Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma (RCC) have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of RCC using hyperpolarized carbon-13 (13C) magnetic resonance imaging (HP-MRI) and describe the validation of in vivo lactate metabolic heterogeneity against multi-regional ex vivo mass spectrometry. HP-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.
Description
Keywords
Renal cell carcinoma, magnetic resonance imaging, metabolism
Journal Title
BJR Case Rep
Conference Name
Journal ISSN
2055-7159
2055-7159
2055-7159
Volume Title
5
Publisher
Oxford University Press (OUP)
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Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/6)
Medical Research Council (MC_UU_12022/6)