Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush; Lo, Ken Sin; Alfred, Tamuno; Mudgal, Poorva; Ng, Maggie CY; Heard-Costa, Nancy L; Feitosa, Mary F; Manning, Alisa K; Willems, Sara M; Sivapalaratnam, Suthesh; Abecasis, Goncalo; Alam, Dewan S; Allison, Matthew; Amouyel, Philippe; Arzumanyan, Zorayr; Balkau, Beverley; Bastarache, Lisa; Bergmann, Sven; Bielak, Lawrence F; Blüher, Matthias; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; Böger, Carsten A; Bork-Jensen, Jette; Bottinger, Erwin P; Bowden, Donald W; Brandslund, Ivan; Broer, Linda; Burt, Amber A; Butterworth, Adam; Caulfield, Mark J; Cesana, Giancarlo; Chambers, John C; Chasman, Daniel I; Chen, Yii-Der Ida; Chowdhury, Rajiv; Christensen, Cramer; Chu, Audrey Y; Collins, Francis S; Cook, James P; Cox, Amanda J; Crosslin, David S; Danesh, John; de Bakker, Paul IW; Denus, Simon de; Mutsert, Renée de; Dedoussis, George; Demerath, Ellen W; Dennis, Joe; Denny, Josh C; Di Angelantonio, Emanuele; Dörr, Marcus; Drenos, Fotios; Dubé, Marie-Pierre; Dunning, Alison; Easton, Douglas; Elliott, Paul; Evangelou, Evangelos; Farmaki, Aliki-Eleni; Feng, Shuang; Ferrannini, Ele; Ferrieres, Jean; Florez, Jose C; Fornage, Myriam; Fox, Caroline S; Franks, Paul W; Friedrich, Nele; Gan, Wei; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Girotto, Giorgia; Gorski, Mathias; Grallert, Harald; Grarup, Niels; Grove, Megan L; Gustafsson, Stefan; Haessler, Jeff; Hansen, Torben; Hattersley, Andrew T; Hayward, Caroline; Heid, Iris M; Holmen, Oddgeir L; Hovingh, G Kees; Howson, Joanna; Hu, Yao; Hung, Yi-Jen; Hveem, Kristian; Ikram, M Arfan; Ingelsson, Erik; Jackson, Anne U; Jarvik, Gail P; Jia, Yucheng; Jørgensen, Torben; Jousilahti, Pekka; Justesen, Johanne M; Kahali, Bratati; Karaleftheri, Maria; Kardia, Sharon LR; Karpe, Fredrik; Kee, Frank; Kitajima, Hidetoshi; Komulainen, Pirjo; Kooner, Jaspal S; Kovacs, Peter; Krämer, Bernhard K; Kuulasmaa, Kari; Kuusisto, Johanna; Laakso, Markku; Lakka, Timo A; Lamparter, David; Lange, Leslie A; Langenberg, Claudia; Larson, Eric B; Lee, Nanette R; Lee, Wen-Jane; Lehtimäki, Terho; Lewis, Cora E; Li, Huaixing; Li, Jin; Li-Gao, Ruifang; Lin, Li-An; Lin, Xu; Lind, Lars; Lindström, Jaana; Linneberg, Allan; Liu, Ching-Ti; Liu, Dajiang J; Luan, Jian'an; Lyytikäinen, Leo-Pekka; MacGregor, Stuart; Mägi, Reedik; Männistö, Satu; Marenne, Gaëlle; Marten, Jonathan; Masca, Nicholas GD; McCarthy, Mark I; Meidtner, Karina; Mihailov, Evelin; Moilanen, Leena; Moitry, Marie; Mook-Kanamori, Dennis O; Morgan, Anna; Morris, Andrew P; Müller-Nurasyid, Martina; Munroe, Patricia B; Narisu, Narisu; Nelson, Christopher P; Neville, Matt; Ntalla, Ioanna; O'Connell, Jeffrey R; Owen, Katharine R; Pedersen, Oluf; Peloso, Gina M; Pennell, Craig E; Perola, Markus; Perry, James A; Perry, John; Pers, Tune H; Ewing, Ailith; Polasek, Ozren; Raitakari, Olli T; Rasheed, Asif; Raulerson, Chelsea K; Rauramaa, Rainer; Reilly, Dermot F; Reiner, Alex P; Ridker, Paul M; Rivas, Manuel A; Robertson, Neil R; Robino, Antonietta; Rudan, Igor; Ruth, Katherine S; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Schreiner, Pamela J; Schulze, Matthias B; Scott, Robert A; Segura-Lepe, Marcelo; Sim, Xueling; Slater, Andrew J; Small, Kerrin S; Smith, Blair H; Smith, Jennifer A; Southam, Lorraine; Spector, Timothy D; Speliotes, Elizabeth K; Stefansson, Kari; Steinthorsdottir, Valgerdur; Stirrups, Kathleen; Strauch, Konstantin; Stringham, Heather M; Stumvoll, Michael; Sun, Liang; Surendran, Praveen; Swart, Karin MA; Tardif, Jean-Claude; Taylor, Kent D; Teumer, Alexander; Thompson, Deborah; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Thuesen, Betina H; Tönjes, Anke; Torres, Mina; Tsafantakis, Emmanouil; Tuomilehto, Jaakko; Uitterlinden, André G; Uusitupa, Matti; van Duijn, Cornelia M; Vanhala, Mauno; Varma, Rohit; Vermeulen, Sita H; Vestergaard, Henrik; Vitart, Veronique; Vogt, Thomas F; Vuckovic, Dragana; Wagenknecht, Lynne E; Walker, Mark; Wallentin, Lars; Wang, Feijie; Wang, Carol A; Wang, Shuai; Wareham, Nicholas; Warren, Helen R; Waterworth, Dawn M; Wessel, Jennifer; White, Harvey D; Willer, Cristen J; Wilson, James G; Wood, Andrew R; Wu, Ying; Yaghootkar, Hanieh; Yao, Jie; Yerges-Armstrong, Laura M; Young, Robin; Zeggini, Eleftheria; Zhan, Xiaowei; Zhang, Weihua; Zhao, Jing Hua; Zhao, Wei; Zheng, He; Zhou, Wei; Zillikens, M Carola; Rivadeneira, Fernando; Borecki, Ingrid B; Pospisilik, J Andrew; Deloukas, Panos; Frayling, Timothy M; Lettre, Guillaume; Mohlke, Karen L; Rotter, Jerome I; Kutalik, Zoltán; Hirschhorn, Joel N; Cupples, L Adrienne; Loos, Ruth JF; North, Kari E; Lindgren, Cecilia M; CHD Exome+ Consortium,; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium,; EPIC-CVD Consortium,; ExomeBP Consortium,; Global Lipids Genetic Consortium,; GoT2D Genes Consortium,; InterAct,; ReproGen Consortium,; T2D-Genes Consortium,; MAGIC Investigators,

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Authors

Justice, Anne E

Karaderi, Tugce

Highland, Heather M

Young, Kristin L

Graff, Mariaelisa

Lu, Yingchang

Turcot, Valérie

Publication Date

2019-03

Journal Title

Nature genetics

ISSN

1061-4036

Volume

Issue

Pages

452-469

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

Show full item record

Citation

Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., et al. (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.. Nature genetics, 51 (3), 452-469. https://doi.org/10.1038/s41588-018-0334-2

Keywords

CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Animals, Humans, Drosophila, Genetic Predisposition to Disease, Lipids, Proteins, Body Mass Index, Waist-Hip Ratio, Risk Factors, Case-Control Studies, Homeostasis, Gene Frequency, Female, Male, Body Fat Distribution, Genetic Variation, Genome-Wide Association Study, Exome

Sponsorship

Cancer Research UK (16565)

MRC (MC_UU_12015/1)

European Commision (37197)

Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)

British Heart Foundation (RG/08/014/24067)

British Heart Foundation (RG/13/13/30194)

MRC (MR/S003746/1)

MRC (MC_UU_12015/2)

Identifiers

External DOI: https://doi.org/10.1038/s41588-018-0334-2

This record's URL: https://www.repository.cam.ac.uk/handle/1810/290292