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dc.contributor.authorChan, Dennis
dc.contributor.authorShafto, Meredith
dc.contributor.authorKievit, Rogier
dc.contributor.authorMatthews, Fiona
dc.contributor.authorSpink, Molly
dc.contributor.authorValenzuela, Michael
dc.contributor.authorHenson, Rik
dc.date.accessioned2019-03-11T14:52:31Z
dc.date.available2019-03-11T14:52:31Z
dc.date.issued2018-10-01
dc.identifier.issn0197-4580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/290421
dc.description.abstractThis study tested the hypothesis that mid-life intellectual, physical and social activities contribute to cognitive reserve (CR). Two hundred and five individuals (196 with MRI) aged 66-88 from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com) were studied, with cognitive ability and structural brain health measured as fluid IQ and total grey matter volume, respectively. Mid-life activities were measured using the Lifetime of Experiences Questionnaire. Multivariable linear regression found that mid-life activities (MA) made a unique contribution to late-life cognitive ability independent of education, occupation and late-life activities. Crucially, MA moderated the relationship between late-life cognitive ability and brain health, with the cognitive ability of people with higher MA less dependent on their brain structure, consistent with the concept of CR. In conclusion, mid-life activities contribute uniquely to CR. The modifiability of these activities has implications for public health initiatives aimed at dementia prevention.
dc.description.sponsorshipCambridge NIHR Biomedical Research Centre
dc.language.isoen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities
dc.typeArticle
prism.endingPage183
prism.publicationDate2018
prism.publicationNameNeurobiology of Aging
prism.startingPage180
prism.volume70
dc.identifier.doi10.17863/CAM.37648
dcterms.dateAccepted2018-06-07
rioxxterms.versionofrecord10.1016/j.neurobiolaging.2018.06.012
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2018-10-01
dc.contributor.orcidChan, Dennis [0000-0002-4265-3718]
dc.contributor.orcidKievit, Rogier [0000-0003-0700-4568]
dc.contributor.orcidMatthews, Fiona [0000-0002-1728-2388]
dc.contributor.orcidHenson, Rik [0000-0002-0712-2639]
dc.identifier.eissn1558-1497
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H008217/1)
pubs.funder-project-idEuropean Commission (732592)
pubs.funder-project-idMedical Research Council (MC_UU_00005/8)
pubs.funder-project-idMedical Research Council (MC_UP_1401/1)
pubs.funder-project-idMedical Research Council (MC_UU_00005/9)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
cam.issuedOnline2018-07-17
rioxxterms.freetoread.startdate2019-07-17


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International