Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities
dc.contributor.author | Chan, Dennis | |
dc.contributor.author | Shafto, Meredith | |
dc.contributor.author | Kievit, Rogier | |
dc.contributor.author | Matthews, Fiona | |
dc.contributor.author | Spink, Molly | |
dc.contributor.author | Valenzuela, Michael | |
dc.contributor.author | Henson, Rik | |
dc.date.accessioned | 2019-03-11T14:52:31Z | |
dc.date.available | 2019-03-11T14:52:31Z | |
dc.date.issued | 2018-10-01 | |
dc.identifier.issn | 0197-4580 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/290421 | |
dc.description.abstract | This study tested the hypothesis that mid-life intellectual, physical and social activities contribute to cognitive reserve (CR). Two hundred and five individuals (196 with MRI) aged 66-88 from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com) were studied, with cognitive ability and structural brain health measured as fluid IQ and total grey matter volume, respectively. Mid-life activities were measured using the Lifetime of Experiences Questionnaire. Multivariable linear regression found that mid-life activities (MA) made a unique contribution to late-life cognitive ability independent of education, occupation and late-life activities. Crucially, MA moderated the relationship between late-life cognitive ability and brain health, with the cognitive ability of people with higher MA less dependent on their brain structure, consistent with the concept of CR. In conclusion, mid-life activities contribute uniquely to CR. The modifiability of these activities has implications for public health initiatives aimed at dementia prevention. | |
dc.description.sponsorship | Cambridge NIHR Biomedical Research Centre | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities | |
dc.type | Article | |
prism.endingPage | 183 | |
prism.publicationDate | 2018 | |
prism.publicationName | Neurobiology of Aging | |
prism.startingPage | 180 | |
prism.volume | 70 | |
dc.identifier.doi | 10.17863/CAM.37648 | |
dcterms.dateAccepted | 2018-06-07 | |
rioxxterms.versionofrecord | 10.1016/j.neurobiolaging.2018.06.012 | |
rioxxterms.version | AM | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
rioxxterms.licenseref.startdate | 2018-10-01 | |
dc.contributor.orcid | Chan, Dennis [0000-0002-4265-3718] | |
dc.contributor.orcid | Kievit, Rogier [0000-0003-0700-4568] | |
dc.contributor.orcid | Matthews, Fiona [0000-0002-1728-2388] | |
dc.contributor.orcid | Henson, Rik [0000-0002-0712-2639] | |
dc.identifier.eissn | 1558-1497 | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | MRC (unknown) | |
pubs.funder-project-id | Biotechnology and Biological Sciences Research Council (BB/H008217/1) | |
pubs.funder-project-id | European Commission (732592) | |
pubs.funder-project-id | Medical Research Council (MC_UU_00005/8) | |
pubs.funder-project-id | Medical Research Council (MC_UP_1401/1) | |
pubs.funder-project-id | Medical Research Council (MC_UU_00005/9) | |
pubs.funder-project-id | Medical Research Council (MC_UU_00005/12) | |
cam.issuedOnline | 2018-07-17 | |
rioxxterms.freetoread.startdate | 2019-07-17 |
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