A roadmap for the clinical implementation of optical-imaging biomarkers
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Waterhouse, Dale J
Fitzpatrick, Catherine RM
Pogue, Brian W
O'Connor, James PB
Bohndiek, Sarah https://orcid.org/0000-0003-0371-8635
Abstract
Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett’s oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical imaging-technologies.
Description
Keywords
Animals, Biomarkers, Early Detection of Cancer, Humans, Melanoma, Optical Imaging, Primary Health Care, Translational Research, Biomedical
Journal Title
Nature Biomedical Engineering
Conference Name
Journal ISSN
2157-846X
2157-846X
2157-846X
Volume Title
3
Publisher
Nature
Publisher DOI
Rights
All rights reserved
Sponsorship
European Commission (630729)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research UK (C14303/A17197)
Engineering and Physical Sciences Research Council (EP/N014588/1)
Cancer Research UK (C14303/A17197)
Cancer Research UK (21102)
Cancer Research UK (24669)
Engineering and Physical Sciences Research Council (EP/R003599/1)
Cancer Research UK (C20/A20976)
Cancer Research UK (A25117)
Cancer Research Uk (None)
Cancer Research Uk (None)
Cancer Research UK (C14303/A17197)
Engineering and Physical Sciences Research Council (EP/N014588/1)
Cancer Research UK (C14303/A17197)
Cancer Research UK (21102)
Cancer Research UK (24669)
Engineering and Physical Sciences Research Council (EP/R003599/1)
Cancer Research UK (C20/A20976)
Cancer Research UK (A25117)