RNA modifications regulating cell fate in cancer.

The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.

Keywords

Cell Differentiation, Cell Lineage, Cell Movement, Cell Proliferation, Cell Survival, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, RNA, RNA Processing, Post-Transcriptional

Journal Title

Nat Cell Biol

Journal ISSN

1465-7392
1476-4679

Volume Title

21

Publisher

Springer Nature

Publisher DOI

https://doi.org/10.1038/s41556-019-0319-0

Rights and licensing

Sponsorship

Cancer Research Uk (None)
European Research Council (310360)
Medical Research Council (MR/M01939X/1)

M.F. is supported by a Cancer Research UK Senior Fellowship (C10701/A15181), the European Research Council (ERC; 310360), and the Medical Research Council UK (MR/M01939X/1). S.D. is funded by an EMBO Long-Term Fellowship. Part of this work was carried out in the framework of the European COST action EPITRAN 16120

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University of Cambridge Research Outputs (Articles and Conferences)