Recent advances in understanding spondyloarthritis.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Gaston, JSH https://orcid.org/0000-0002-5789-5111
Abstract
This review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is implicated in inflammation is also considered, together with recent and contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27 expression and hence susceptibility to spondylitis. Lastly, a recent report on the role of the gut microbiome in an important model of spondyloarthritis is considered.
Description
Keywords
ERAP1, HLA-B27, enthesitis, gut microbiome, spondyloarthritis
Journal Title
F1000Res
Conference Name
Journal ISSN
2046-1402
1759-796X
1759-796X
Volume Title
6
Publisher
F1000 Research Ltd