The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Ji, Zongling
Mohammed, Hisham
Webber, Aaron
Ridsdale, Jenna
Han, Namshik https://orcid.org/0000-0002-7741-6384
Abstract
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function across multiple cell types. Here, we show that FOXK2 binds to the SIN3A and PR-DUB complexes. The PR-DUB complex contains the important tumour suppressor protein, the deubiquitinase BAP1. FOXK2 recruits BAP1 to DNA, promotes local histone deubiquitination and causes changes in target gene activity. Our results therefore provide an important link between BAP1 and the transcription factor FOXK2 and demonstrate how BAP1 can be recruited to specific regulatory loci.
Description
Keywords
Cell Line, Chromatin, Forkhead Transcription Factors, Gene Expression Regulation, Genome, Humans, Protein Interaction Domains and Motifs, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Tumor Suppressor Proteins, Ubiquitin Thiolesterase
Journal Title
Nucleic Acids Res
Conference Name
Journal ISSN
0305-1048
1362-4962
1362-4962
Volume Title
42
Publisher
Oxford University Press (OUP)
Publisher DOI
Sponsorship
Cancer Research UK (C14303/A17197)