Host-pathogen coevolution increases genetic variation in susceptibility to infection.
Maria Vespasiani, Davide
Smith, Sophia Cl
eLife Sciences Publications Ltd
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Duxbury, E. M., Day, J., Maria Vespasiani, D., Thüringer, Y., Tolosana, I., Smith, S. C., Tagliaferri, L., et al. (2019). Host-pathogen coevolution increases genetic variation in susceptibility to infection.. eLife, 8 https://doi.org/10.7554/elife.46440
It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations.
Animals, Drosophila melanogaster, Rhabdoviridae, Rhabdoviridae Infections, Disease Susceptibility, Viral Load, Chromosome Mapping, Species Specificity, Polymorphism, Genetic, Alleles, Genes, Insect, Female, Male, Host-Pathogen Interactions, Genetic Variation, Selection, Genetic, Disease Resistance, Infections
European Research Council (281668)
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External DOI: https://doi.org/10.7554/elife.46440
This record's URL: https://www.repository.cam.ac.uk/handle/1810/292045
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