Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.

Shu, Shaokun; Lin, Charles Y; He, Housheng Hansen; Witwicki, Robert M; Tabassum, Doris P; Roberts, Justin M; Janiszewska, Michalina; Huh, Sung Jin; Liang, Yi; Ryan, Jeremy; Doherty, Ernest; Mohammed, Hisham; Guo, Hao; Stover, Daniel G; Ekram, Muhammad B; Brown, Jonathan; D'Santos, Clive; Krop, Ian E; Dillon, Deborah; McKeown, Michael; Ott, Christopher; Qi, Jun; Ni, Min; Rao, Prakash K; Duarte, Melissa; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Anders, Lars; Young, Richard A; Winer, Eric; Letai, Antony; Barry, William T; Carroll, Jason; Long, Henry; Brown, Myles; Liu, X Shirley; Meyer, Clifford A; Bradner, James E; Polyak, Kornelia

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Authors

Shu, Shaokun

Lin, Charles Y

He, Housheng Hansen

Witwicki, Robert M

Tabassum, Doris P

Roberts, Justin M

Janiszewska, Michalina

Publication Date

2016-01-06

Journal Title

Nature

ISSN

0028-0836

Volume

529

Issue

7586

Pages

413-417

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., et al. (2016). Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.. Nature, 529 (7586), 413-417. https://doi.org/10.1038/nature16508

Keywords

Cell Line, Tumor, Chromatin, Animals, Humans, Mice, Azepines, Triazoles, Casein Kinase II, Phosphoserine, Cell Cycle Proteins, Nuclear Proteins, Transcription Factors, Xenograft Model Antitumor Assays, Proteomics, Cell Proliferation, Transcription, Genetic, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Binding, Competitive, Protein Structure, Tertiary, Protein Binding, Phosphorylation, Drug Resistance, Neoplasm, Genome, Human, Female, Protein Phosphatase 2, Mediator Complex Subunit 1, Triple Negative Breast Neoplasms

Sponsorship

Cancer Research UK (C14303_do not transfer)

Identifiers

External DOI: https://doi.org/10.1038/nature16508

This record's URL: https://www.repository.cam.ac.uk/handle/1810/292234