Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

Ju, Young Seok; Martincorena, Inigo; Gerstung, Moritz; Petljak, Mia; Alexandrov, Ludmil B; Rahbari, Raheleh; Wedge, David C; Davies, Helen; Ramakrishna, Manasa; Fullam, Anthony; Martin, Sancha; Alder, Christopher; Patel, Nikita; Gamble, Steve; O'Meara, Sarah; Giri, Dilip D; Sauer, Torril; Pinder, Sarah E; Purdie, Colin A; Borg, Åke; Stunnenberg, Henk; van de Vijver, Marc; Tan, Benita KT; Caldas, Carlos; Tutt, Andrew; Ueno, Naoto T; van 't Veer, Laura J; Martens, John WM; Sotiriou, Christos; Knappskog, Stian; Span, Paul N; Lakhani, Sunil R; Eyfjörd, Jórunn Erla; Børresen-Dale, Anne-Lise; Richardson, Andrea; Thompson, Alastair M; Viari, Alain; Hurles, Matthew E; Nik-Zainal Abidin, Serena; Campbell, Peter J; Stratton, Michael R

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Authors

Ju, Young Seok

Martincorena, Inigo

Gerstung, Moritz

Petljak, Mia

Alexandrov, Ludmil B

Rahbari, Raheleh

Wedge, David C

Publication Date

2017-03-22

Journal Title

Nature

ISSN

0028-0836

Volume

543

Issue

7647

Pages

714-718

Language

eng

Type

Article

This Version

Physical Medium

Print-Electronic

Metadata

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Citation

Ju, Y. S., Martincorena, I., Gerstung, M., Petljak, M., Alexandrov, L. B., Rahbari, R., Wedge, D. C., et al. (2017). Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.. Nature, 543 (7647), 714-718. https://doi.org/10.1038/nature21703

Keywords

Blood Cells, Humans, Mutagenesis, Cell Lineage, Embryonic Development, Mutation, Mosaicism, Germ-Line Mutation, Genome, Human, Adult, Embryo, Mammalian, Mutation Rate

Identifiers

External DOI: https://doi.org/10.1038/nature21703

This record's URL: https://www.repository.cam.ac.uk/handle/1810/292461