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Obsessive-Compulsive Disorder: Puzzles and Prospects.

Accepted version
Peer-reviewed

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Authors

Robbins, Trevor W 
Vaghi, Matilde M 
Banca, Paula 

Abstract

Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents several challenges for neuroscience. Recent advances in its genetic and developmental causation, as well as its neuropsychological basis, are reviewed. Hypotheses concerning an imbalance between goal-directed and habitual behavior together with neural correlates in cortico-striatal circuitry are evaluated and contrasted with metacognitive theories. Treatments for obsessive-compulsive disorder (OCD) tend to be of mixed efficacy but include psychological, pharmacological, and surgical approaches, the underlying mechanisms of which are still under debate. Overall, the prospects for new animal models and an integrated understanding of the pathophysiology of OCD are considered in the context of dimensional psychiatry.

Description

Keywords

cognitive-behavioral therapy, deep brain stimulation, executive function, glutamate, goal-directed behavior, habit, obsessive compulsive disorder, prefrontal cortex, serotonin, striatum

Journal Title

Neuron

Conference Name

Journal ISSN

0896-6273
1097-4199

Volume Title

102

Publisher

Elsevier
Sponsorship
Wellcome Trust (104631/Z/14/Z)
Wellcome Trust (204727/Z/16/Z)
This work was supported by a Wellcome Trust Senior Investigator Award (104631/Z/14/Z) to T.W.R., an Angharad Dodds John Bursary in Mental Health and Neuropsychiatry to M.M.V., and a Sir Henry Wellcome Trust Postdoctoral Research Fellowship (RG86232) to P.B.