Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells
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Abstract
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involve bond cleavage to release a molecule of interest. The trans-cyclooctene (TCO)-tetrazine inverse electron-demand Diels–Alder reaction has been...
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Organic & Biomolecular Chemistry
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1477-0520
1477-0539
1477-0539
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Royal Society of Chemistry (RSC)
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702574)
Royal Society (URF\R\180019)
EPSRC (1800475)
Royal Society (URF\R\180019)
EPSRC (1800475)
We thank the EPSRC (PhD studentship to S. D.), the European Commission (Marie Sklodowska-Curie Fellowship to B. L. O., GA No. 702574) and FCT Portugal (iFCT IF/00624/2015 and 02/SAICT/2017, Grant 28333). G. J. L. B. is a Royal Society University Research Fellow (URF\R\180019).