Severe neurodevelopmental disease caused by a homozygous TLK2 variant.
European journal of human genetics : EJHG
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Töpf, A., Oktay, Y., Balaraju, S., Yilmaz, E., Sonmezler, E., Yis, U., Laurie, S., et al. (2019). Severe neurodevelopmental disease caused by a homozygous TLK2 variant.. European journal of human genetics : EJHG https://doi.org/10.1038/s41431-019-0519-x
A distinct neurodevelopmental phenotype characterised mainly by mild motor and language delay and facial dysmorphism, caused by heterozygous de novo or dominant variants in the TLK2 gene has recently been described. All cases reported carried either truncating variants located throughout the gene, or missense changes principally located at the C-terminal end of the protein mostly resulting in haploinsufficiency of TLK2. Through whole exome sequencing, we identified a homozygous missense variant in TLK2 in a patient showing more severe symptoms than those previously described, including cerebellar vermis hypoplasia and West syndrome. Both parents are heterozygous for the variant and clinically unaffected highlighting that recessive variants in TLK2 can also be disease-causing and may act through a different pathomechanism.
RH is a Wellcome Trust Investigator (109915/Z/15/Z), who receives support from the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z), Medical Research Council (UK) (MR/N025431/1), the European Research Council (309548), the Wellcome Trust Pathfinder Scheme (201064/Z/16/Z) and the Newton Fund (UK/Turkey, MR/N027302/1).
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External DOI: https://doi.org/10.1038/s41431-019-0519-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293649
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