Show simple item record

dc.contributor.authorVasiliauskaitė, Lina
dc.contributor.authorVitsios, Dimitrios
dc.contributor.authorBerrens, Rebecca V
dc.contributor.authorCarrieri, Claudia
dc.contributor.authorReik, Wolf
dc.contributor.authorEnright, Anton
dc.contributor.authorO'Carroll, Dónal
dc.date.accessioned2019-06-17T23:31:45Z
dc.date.available2019-06-17T23:31:45Z
dc.date.issued2017-07
dc.identifier.issn1545-9993
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/293701
dc.description.abstractIn mice, the pathway involving PIWI and PIWI-interacting RNA (PIWI-piRNA) is essential to re-establish transposon silencing during male-germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2's binding to piRNA and its nuclear localization are proposed to be dependent upon MILI function. Here, we demonstrate the existence of a piRNA biogenesis pathway that sustains partial MIWI2 function and reprogramming activity in the absence of MILI.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectMice, Knockout
dc.subjectMice
dc.subjectRNA, Small Interfering
dc.subjectGene Expression Regulation
dc.subjectArgonaute Proteins
dc.titleA MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.
dc.typeArticle
prism.endingPage606
prism.issueIdentifier7
prism.publicationDate2017
prism.publicationNameNat Struct Mol Biol
prism.startingPage604
prism.volume24
dc.identifier.doi10.17863/CAM.40813
dcterms.dateAccepted2017-04-26
rioxxterms.versionofrecord10.1038/nsmb.3413
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-07
dc.contributor.orcidVasiliauskaitė, Lina [0000-0003-0926-3862]
dc.contributor.orcidVitsios, Dimitrios [0000-0002-8939-5445]
dc.contributor.orcidReik, Wolf [0000-0003-0216-9881]
dc.contributor.orcidEnright, Anton [0000-0002-6090-3100]
dc.identifier.eissn1545-9985
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-05-22
rioxxterms.freetoread.startdate2018-01-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record