Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.
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Sveiczer, A., North, A. J., Mateu, N., Kidd, S. L., Sore, H., & Spring, D. (2019). Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.. Organic letters, 21 (12), 4600-4604. https://doi.org/10.1021/acs.orglett.9b01499
Novel divergent methodology to access sp3-rich spirocyclic fragments is reported. First, a robust modular synthesis of bis-alkene amino ester building blocks was developed. Three different carbocycles and six heterocycles were then constructed to assemble eight spirocycles. Importantly, strategic exit vectors were incorporated within each scaffold to aid fragment growth and were elaborated via chemical modifications. Finally, computational methods demonstrate higher levels of rigidity, three-dimensionality, and structural diversity of the library compared to a commercial collection.
External DOI: https://doi.org/10.1021/acs.orglett.9b01499
This record's URL: https://www.repository.cam.ac.uk/handle/1810/293774
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