11 C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Surendranathan, Ajenthan
Mak, Elijah
Rowe, James B
O'Brien, John T
Abstract
There is evidence of increased microglial activation in Parkinson's disease (PD) as shown by in vivo PET ligand such as 11 C-PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson's disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher 11 C-PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions.
Description
Keywords
Aged, Aged, 80 and over, Amides, Dementia, Diffusion Tensor Imaging, Humans, Inflammation, Isoquinolines, Male, Microglia, Parkinson Disease, Positron-Emission Tomography, White Matter
Journal Title
Ann Clin Transl Neurol
Conference Name
Journal ISSN
2328-9503
2328-9503
2328-9503
Volume Title
6
Publisher
Wiley
Publisher DOI
Rights
All rights reserved
Sponsorship
Wellcome Trust (103838/Z/14/Z)
Alzheimer's Society (443 (AS-JF-18-017))
Medical Research Council (MR/M009041/1)
Alzheimer's Society (443 (AS-JF-18-017))
Medical Research Council (MR/M009041/1)
We are grateful to our volunteers for their participation in the study. We thank the radiographers at Wolfson Brain Imaging Centre and the PET/CT unit, Addenbrooke's Hospital for their technical expertise and support in data acquisition. We thank Alzheimer Research UK, the National Institute for Health Research Cambridge Biomedical Research Centre (NIHR, RG64473) and the Wellcome Trust (JBR: 103838) for funding and support.