Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.
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Castro-Bravo, N., Margolles, A., Wells, J., & Ruas-Madiedo, P. (2019). Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.. Anaerobe, 56 98-101. https://doi.org/10.1016/j.anaerobe.2019.02.014
The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass.
Bifidobacterium animalis, Cell Line, Epithelial Cells, Humans, Polysaccharides, Bacterial, Protein Binding, Toll-Like Receptor 4
The MicroHealth group acknowledge the project AGL2015-64901-R (including FEDER European Union funds) from the Ministry of Economy, Industry and Competiveness (MINECO). N. Castro-Bravo thanks her FPI fellowship to the MINECO (BES2013-063984).
External DOI: https://doi.org/10.1016/j.anaerobe.2019.02.014
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297929
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/