Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.

The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass.

Keywords

Bifidobacterium animalis, Cell Line, Epithelial Cells, Humans, Polysaccharides, Bacterial, Protein Binding, Toll-Like Receptor 4

Journal Title

Anaerobe

Journal ISSN

1075-9964
1095-8274

Volume Title

56

Publisher

Elsevier

Publisher DOI

https://doi.org/10.1016/j.anaerobe.2019.02.014

Rights and licensing

Except where otherwised noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

Sponsorship

The MicroHealth group acknowledge the project AGL2015-64901-R (including FEDER European Union funds) from the Ministry of Economy, Industry and Competiveness (MINECO). N. Castro-Bravo thanks her FPI fellowship to the MINECO (BES2013-063984).

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University of Cambridge Research Outputs (Articles and Conferences)