Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
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Houldcroft, C. (2019). Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion. Pathogens, 8 (4. 186)https://doi.org/10.3390/pathogens8040186
The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enrichment and long-read sequencing. It will also look at the problem of resolving mixed-genotype infections, whether with short or long-read sequencing methods; and conclude with some thoughts on the future of the field as herpesvirus population genomics becomes a reality.
This research received no external funding.
Wellcome Trust (via University College London (UCL)) (Ref 17/0008 539724)
External DOI: https://doi.org/10.3390/pathogens8040186
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297958
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/