Evidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis.
Nature Publishing Group
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Seddighi, S., Houck, A. L., Rowe, J., & Pharoah, P. (2019). Evidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis.. Scientific Reports, 9 (1. 13548)https://doi.org/10.1038/s41598-019-49795-6
While limited observational evidence suggests that cancer survivors have a decreased risk of developing Alzheimer's disease (AD), and vice versa, it is not clear whether this relationship is causal. Using a Mendelian randomization approach that provides evidence of causality, we found that genetically predicted lung cancer (OR 0.91, 95% CI 0.84-0.99, p = 0.019), leukemia (OR 0.98, 95% CI 0.96-0.995, p = 0.012), and breast cancer (OR 0.94, 95% CI 0.89-0.99, p = 0.028) were associated with 9.0%, 2.4%, and 5.9% lower odds of AD, respectively, per 1-unit higher log odds of cancer. When genetic predictors of all cancers were pooled, cancer was associated with 2.5% lower odds of AD (OR 0.98, 95% CI 0.96-0.988, p = 0.00027) per 1-unit higher log odds of cancer. Finally, genetically predicted smoking-related cancers showed a more robust inverse association with AD than non-smoking related cancers (OR 0.95, 95% CI 0.92-0.98, p = 0.0026, vs. OR 0.98, 95% CI 0.97-0.995, p = 0.0091).
This project was supported by a Gates Cambridge Trust grant to SS (OPP1144). JBR is supported by the Wellcome Trust (103838). PDPP has infrastructural support from Cambridge University and Cancer Research UK.
WELLCOME TRUST (103838/Z/14/Z)
External DOI: https://doi.org/10.1038/s41598-019-49795-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/297987
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/