Imaging at the inter-face of inflammation and angiogenesis by 18F-fluciclatide PET
BMJ Publishing Group
MetadataShow full item record
Tarkin, J. (2019). Imaging at the inter-face of inflammation and angiogenesis by 18F-fluciclatide PET. Heart https://doi.org/10.1136/heartjnl-2019-315487
Mechanisms underlying atherosclerotic plaque rupture are complex and unpredictable by any current imaging test. However, several key pathogenic processes known to increase the likelihood of an acute plaque event can be tracked in vivo using positron emission tomography (PET). In this issue of Heart, Jenkins et al. examine the utility of 18F-fluciclatide, an v3integrin binding PET tracer, for imaging atherosclerosis. This intriguing study adds great momentum in the push to identify novel methods for imaging molecular signatures of high-risk plaques, and raises several important broader considerations for the field.
J.M.T. is supported by a Wellcome Trust Clinical Research Career Development Fellowship (211100/Z/18/Z) and the National Institute for Health Research (NIHR). J.C.M. acknowledges support from the Imperial NIHR Biomedical Research Centre. Z.A.F is supported by the NIH (P01 HL131478, R01 HL071021, R01 HL128056, R01HL135878, NBIB R01 EB009638) and the American Heart Association (14SFRN20780005).
Wellcome Trust (211100/Z/18/Z)
External DOI: https://doi.org/10.1136/heartjnl-2019-315487
This record's URL: https://www.repository.cam.ac.uk/handle/1810/298754