Fear not: recent advances in understanding the neural basis of fear memories and implications for treatment development.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Milton, Amy L https://orcid.org/0000-0003-0175-9417
Abstract
Fear is a highly adaptive emotion that has evolved to promote survival and reproductive fitness. However, maladaptive expression of fear can lead to debilitating stressor-related and anxiety disorders such as post-traumatic stress disorder. Although the neural basis of fear has been extensively researched for several decades, recent technological advances in pharmacogenetics and optogenetics have allowed greater resolution in understanding the neural circuits that underlie fear. Alongside conceptual advances in the understanding of fear memory, this increased knowledge has clarified mechanisms for some currently available therapies for post-traumatic stress disorder and has identified new potential treatment targets.
Description
Keywords
PTSD, amygdala, fear, hippocampus, infralimbic, memory, prelimbic, reconsolidation, Fear, Humans, Memory, Stress Disorders, Post-Traumatic
Journal Title
F1000Res
Conference Name
Journal ISSN
2046-1402
2046-1402
2046-1402
Volume Title
8
Publisher
F1000 Research Ltd
Publisher DOI
Sponsorship
Medical Research Council (MR/N02530X/1)