Decoding the Notch signal.
Development, growth & differentiation
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Falo-Sanjuan, J., & Bray, S. (2020). Decoding the Notch signal.. Development, growth & differentiation, 62 (1), 4-14. https://doi.org/10.1111/dgd.12644
Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limiting amounts of nuclear activity. Here we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.
Animals, Humans, Signal Transduction, Receptors, Notch, Transcriptional Activation
Wellcome Trust (212207/Z/18/Z)
WELLCOME TRUST (109144/Z/15/Z)
Embargo Lift Date
External DOI: https://doi.org/10.1111/dgd.12644
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300223
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