Decoding the Notch signal.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Falo-Sanjuan, Julia
Bray, Sarah J https://orcid.org/0000-0002-1642-599X
Abstract
Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.
Description
Keywords
Notch, gene regulation, signalling, transcription, Animals, Humans, Receptors, Notch, Signal Transduction, Transcriptional Activation
Journal Title
Dev Growth Differ
Conference Name
Journal ISSN
0012-1592
1440-169X
1440-169X
Volume Title
62
Publisher
Wiley
Publisher DOI
Rights
All rights reserved
Sponsorship
Medical Research Council (MR/L007177/1)
Wellcome Trust (212207/Z/18/Z)
Wellcome Trust (109144/Z/15/Z)
Wellcome Trust (212207/Z/18/Z)
Wellcome Trust (109144/Z/15/Z)