The use of biophysical approaches to understand ciliary beating.
Biochemical Society transactions
Portland Press, Ltd.
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Cicuta, P. (2020). The use of biophysical approaches to understand ciliary beating.. Biochemical Society transactions, 48 (1), 221-229. https://doi.org/10.1042/bst20190571
Motile cilia are a striking example of functional cellular organelle, conserved across all the eukaryotic species. Motile cilia allow swimming of cells and small organisms and transport of liquids across epithelial tissues. Whilst the molecular structure is now very well understood, the dynamics of cilia is not well established either at the single cilium level nor at the level of collective beating. Indeed, a full understanding of this requires connecting together behaviour across various lengthscales, from the molecular to the organelle, then at cellular level and up to the tissue scale. Aside from the fundamental interest in this system, understanding beating is important to elucidate aspects of embryonic development and a variety of health conditions from fertility to genetic and infectious diseases of the airways.
Respiratory Mucosa, Epithelium, Cilia, Flagella, Organelles, Eukaryotic Cells, Animals, Humans, Biophysical Phenomena, Hydrodynamics
ERC HydroSync, and CF TRust
European Research Council (614966)
External DOI: https://doi.org/10.1042/bst20190571
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300389
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