Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men.
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Janus, C., Vistisen, D., Amadid, H., Witte, D. R., Lauritzen, T., Brage, S., Bjerregaard, A., et al. (2019). Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men.. Endocrine connections, 8 (12), 1607-1617. https://doi.org/10.1530/ec-19-0408
Abstract RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals. METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis. RESULTS: In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men. CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.
S B was supported by the UK Medical Research Council (MC_UU_12015/3) and the NIHR Biomedical Research Centre Cambridge (IS-BRC-1215-20014).
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
External DOI: https://doi.org/10.1530/ec-19-0408
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300756
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/