Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster.

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Authors
Lewis, Jo E.
Monnier, Chloe
Marshall, Hayley
Fowler, Maxine
Green, Rebecca
Cooper, Scott
Chiotellis, Aristeidis
Publication Date
2019-11-09
ISSN
2212-8778
Language
eng
Type
Article
This Version
VoR
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Citation
Lewis, J. E., Monnier, C., Marshall, H., Fowler, M., Green, R., Cooper, S., Chiotellis, A., et al. (2019). Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster.. https://doi.org/10.1016/j.molmet.2019.10.009
Abstract
Highlights•FGF21 increases glucose and lipid uptake in adipose tissue.•The selective FGF21-induced increase in lipid uptake in BAT may fuel thermogenesis.•Unlike BAT, glucose uptake in WAT may be used for lipogenesis.
Keywords
Brown adipose tissue, Glucose uptake, White Adipose Tissue, Fgf21, Lipid Uptake, Β-klotho
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M001555/1)
Identifiers
PMC6889485
External DOI: https://doi.org/10.1016/j.molmet.2019.10.009
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300894

Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International