Endoplasmic reticulum stress in malignancy.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Clarke, Hanna J
Chambers, Joseph E
Liniker, Elizabeth
Marciniak, Stefan J
Abstract
The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
Description
Keywords
Activating Transcription Factor 6, Antineoplastic Agents, Boronic Acids, Bortezomib, Cell Proliferation, Cell Survival, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Endoribonucleases, Humans, Neoplasms, Neovascularization, Pathologic, Protein Folding, Protein Serine-Threonine Kinases, Pyrazines, Unfolded Protein Response, eIF-2 Kinase
Journal Title
Cancer Cell
Conference Name
Journal ISSN
1535-6108
1878-3686
1878-3686
Volume Title
25
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Medical Research Council (G1002610)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)
Medical Research Council (G0601840)
Wellcome Trust (100140/Z/12/Z)