Understanding the genetic basis of congenital insensitivity to pain.
British medical bulletin
Oxford University Press
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Drissi, I., Woods, W. A., & Woods, G. (2020). Understanding the genetic basis of congenital insensitivity to pain.. British medical bulletin, 133 (1), 65-78. https://doi.org/10.1093/bmb/ldaa003
Congenital Insensitivity to Pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness. Whilst only a small number of causative conditions and genes are known, most have led to profound insights into human nociception. CIP gene discovery is catalysing the manufacture of completely new classes of analgesics; and these are needed as alternatives to synthetic highly potent opioids, which in the USA especially has led to an “epidemic” of dependant users and deaths following overdose.
Humans, Pain Insensitivity, Congenital, Nerve Tissue Proteins, Signal Transduction, Drug Discovery, Nociception, Pharmacogenomic Testing
Wellcome Trust Cambridge NIHR Biomedical Research Centre
Cambridge University Hospitals NHS Foundation Trust (CUH) (3819-1415-50)
Wellcome Trust (via University College London (UCL)) (532344)
External DOI: https://doi.org/10.1093/bmb/ldaa003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/302789
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