Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.
Santangelo, Andrea Mariana
The Journal of neuroscience : the official journal of the Society for Neuroscience
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Quah, S., McIver, L., Roberts, A., & Santangelo, A. M. (2020). Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40 (24), 4739-4749. https://doi.org/10.1523/jneurosci.2930-19.2020
Findings here contribute to our understanding of how the serotonin system underlies an individual’s expression of threat-elicited negative emotions such as anxiety and fear within nonhuman primates. Exploration of serotonergic gene expression across brain regions implicated in emotion regulation revealed that serotonin transporter gene expression in the ventrolateral prefrontal cortex and most strongly in the amygdala, but none of the serotonin receptor genes, were predictive of inter-individual differences in anxiety-like behaviour. Targeting of amygdala serotonin reuptake with selective serotonin reuptake inhibitors confirmed the causal relationship between amygdala serotonin transporter and an animal’s sensitivity to threat by reversing expression of two key features of the high trait-like anxiety phenotype: high responsivity to anxiety-provoking uncertain threat and responsivity to certain conditioned threat.
Amygdala, Animals, Callithrix, Humans, Citalopram, Receptors, Serotonin, Serotonin Uptake Inhibitors, Behavior, Animal, Exploratory Behavior, Emotions, Anxiety, Fear, Female, Male, Serotonin Plasma Membrane Transport Proteins, Extinction, Psychological
Medical Research Council (MR/M023990/1)
External DOI: https://doi.org/10.1523/jneurosci.2930-19.2020
This record's URL: https://www.repository.cam.ac.uk/handle/1810/303680
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