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A variational model dedicated to joint segmentation, registration, and atlas generation for shape analysis

Published version
Peer-reviewed

Type

Article

Change log

Authors

Debroux, N 
Aston, J 
Bonardi, F 
Forbes, A 
Le Guyader, C 

Abstract

In medical image analysis, constructing an atlas, i.e., a mean representative of an ensemble of images, is a critical task for practitioners to estimate variability of shapes inside a population, and to characterize and understand how structural shape changes have an impact on health. This involves identifying significant shape constituents of a set of images, a process called segmentation, and mapping this group of images to an unknown mean image, a task called registration, making a statistical analysis of the image population possible. To achieve this goal, we propose treating these operations jointly to leverage their positive mutual influence, in a hyperelasticity setting, by viewing the shapes to be matched as Ogden materials. The approach is complemented by novel hard constraints on the L\infty norm of both the Jacobian and its inverse, ensuring that the deformation is a bi-Lipschitz homeomorphism. Segmentation is based on the Potts model, which allows for a partition into more than two regions, i.e., more than one shape. The connection to the registration problem is ensured by the dissimilarity measure that aims to align the segmented shapes. A representation of the deformation field in a linear space equipped with a scalar product is then computed in order to perform a geometry-driven Principal Component Analysis (PCA) and to extract the main modes of variations inside the image population. Theoretical results emphasizing the mathematical soundness of the model are provided, among which are existence of minimizers, analysis of a numerical method, asymptotic results, and a PCA analysis, as well as numerical simulations demonstrating the ability of the model to produce an atlas exhibiting sharp edges, high contrast, and a consistent shape.

Description

Keywords

46 Information and Computing Sciences, 4603 Computer Vision and Multimedia Computation

Journal Title

SIAM Journal on Imaging Sciences

Conference Name

Journal ISSN

1936-4954
1936-4954

Volume Title

13

Publisher

Society for Industrial & Applied Mathematics (SIAM)

Rights

All rights reserved
Sponsorship
Leverhulme Trust (RPG-2015-250)
Engineering and Physical Sciences Research Council (EP/N014588/1)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (691070)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (777826)
Leverhulme Trust (PLP-2017-275)
National Physical Laboratory (NPL) (Unknown)
Alan Turing Institute (Unknown)
Engineering and Physical Sciences Research Council (EP/M00483X/1)
Engineering and Physical Sciences Research Council (EP/J009539/1)
EPSRC (EP/S026045/1)