Association of preeclampsia with anthropometric measures and blood pressure in Indian children.
Authors
Randhir, Karuna
Pisal, Hemlata
Kadam, Vrushali
Khaire-Ghadge, Amrita
Malshe, Nandini
Deshpande, Ruma
Palkar, Sonali
Lalwani, Sanjay
Kumaran, Kalyanaraman
Yajnik, Chittaranjan
Osmond, Clive
Fall, Caroline
Publication Date
2020Journal Title
PLoS One
ISSN
1932-6203
Publisher
Public Library of Science (PLoS)
Volume
15
Issue
5
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Randhir, K., Pisal, H., Kadam, V., Khaire-Ghadge, A., Malshe, N., Deshpande, R., Palkar, S., et al. (2020). Association of preeclampsia with anthropometric measures and blood pressure in Indian children.. PLoS One, 15 (5) https://doi.org/10.1371/journal.pone.0231989
Abstract
BACKGROUND AND OBJECTIVE: Birth weight and post-natal growth are important predictors of adult health. Preeclampsia (PE) is associated with low birth weight and may have long term effects on the health of the children. The current study aims to compare anthropometry and blood pressure between children of mothers with and without PE in an Indian cohort. METHODS: We studied children born to women with (PE; n = 211) and without preeclampsia (non-PE; n = 470) at Bharati Hospital, Pune, India. Anthropometry and blood pressure were measured in children at 3-7 years of age. Weight and height Z-scores were calculated using the WHO 2006 growth reference. Independent t-tests were used to compare means between the two groups, and associations between preeclampsia and child outcomes were analyzed using multiple linear regression, adjusting for potential confounders. RESULTS: Weight and height Z-scores (p = 0.04 and 0.008), and subscapular skinfold thickness (p = 0.03) were higher among children of PE compared with children of non-PE mothers. Systolic blood pressure was also higher in children of PE mothers (1.70 mmHg [95% CI 0.05, 2.90] p = 0.006). BMI and diastolic blood pressure did not differ between groups. In regression models adjusted for newborn weight and gestational age, current age and sex, and maternal height, BMI and socio-economic status, children of PE mothers had higher weight Z-score (0.27 SD [95%CI 0.06, 0.48] p = 0.01), height Z-score (0.28 SD [95%CI 0.09, 0.47] p = 0.005), and subscapular skinfold thickness (0.38 mm [95%CI 0.00, 0.76] p = 0.049). A trend for higher systolic blood pressure (1.59 mmHg [95%CI -0.02, 3.20] p = 0.053) in the children was also observed in the adjusted model. The difference in systolic blood pressure was attenuated after adjusting further for the child's weight and height (1.09 mmHg [95%CI -0.48, 2.67] p = 0.17). There was no evidence of differences in effects between boys and girls. CONCLUSION: Children of PE mothers were taller and heavier, and had higher systolic blood pressure, partly explained by their increased body size, than children of non-PE mothers. In utero exposure to preeclampsia may increase the risk of future cardiovascular disease.
Keywords
Research Article, Medicine and health sciences, People and places, Biology and life sciences
Sponsorship
Department of Biotechnology (BT/PR10596/PFN/20/995/201)
Wellcome Trust supplementary grant (098575/Z/12/Z)
Identifiers
pone-d-20-01076
External DOI: https://doi.org/10.1371/journal.pone.0231989
This record's URL: https://www.repository.cam.ac.uk/handle/1810/305016
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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