The challenge of early detection in cancer.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Pashayan, Nora
Pharoah, Paul DP
Abstract
jats:pTumor growth dynamics and the timing of metastasis impose limits on cancer screening</jats:p>
Description
Keywords
Early Detection of Cancer, Humans, Neoplasm Metastasis, Neoplasms, Randomized Controlled Trials as Topic
Journal Title
Science
Conference Name
Journal ISSN
0036-8075
1095-9203
1095-9203
Volume Title
368
Publisher
American Association for the Advancement of Science (AAAS)
Publisher DOI
Rights
All rights reserved
Sponsorship
Multiple developments in imaging and biomarkers have shown promise as tests for the earlier detection of cancer, but a prerequisite for their success in reducing death from cancer is taking into account heterogeneity of tumour growth kinetics and the relationship between tumour size and metastatic potential.