Show simple item record

dc.contributor.authorAlendar, Andrej
dc.contributor.authorLambooij, Jan-Paul
dc.contributor.authorBhaskaran, Rajith
dc.contributor.authorLancini, Cesare
dc.contributor.authorSong, Ji-Ying
dc.contributor.authorvan Vugt, Huub
dc.contributor.authorSnoek, Margriet
dc.contributor.authorBerns, Anton
dc.date.accessioned2020-05-27T01:55:28Z
dc.date.available2020-05-27T01:55:28Z
dc.date.issued2020-05-26
dc.date.submitted2020-02-07
dc.identifier.otherpone-d-20-01303
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305810
dc.description.abstractChromodomain helicase DNA-binding (CHD) chromatin remodelers regulate transcription and DNA repair. They govern cell-fate decisions during embryonic development and are often deregulated in human pathologies. Chd1-8 show upon germline disruption pronounced, often developmental lethal phenotypes. Here we show that contrary to Chd1-8 disruption, Chd9–/–animals are viable, fertile and display no developmental defects or disease predisposition. Germline deletion of Chd9 only moderately affects gene expression in tissues and derived cells, whereas acute depletion in human cancer cells elicits more robust changes suggesting that CHD9 is a highly context-dependent chromatin regulator that, surprisingly, is dispensable for mouse development.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectResearch and analysis methods
dc.titleGene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development
dc.typeArticle
dc.date.updated2020-05-27T01:55:27Z
prism.issueIdentifier5
prism.publicationNamePLOS ONE
prism.volume15
dc.identifier.doi10.17863/CAM.52890
dcterms.dateAccepted2020-05-04
rioxxterms.versionofrecord10.1371/journal.pone.0233394
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Coppola, Vincenzo
dc.contributor.orcidAlendar, Andrej [0000-0001-8271-3650]
dc.contributor.orcidSnoek, Margriet [0000-0002-1904-3823]
dc.contributor.orcidBerns, Anton [0000-0003-2194-1988]
dc.identifier.eissn1932-6203
pubs.funder-project-idKWF Kankerbestrijding (Queen Wilhelmina Research Prize)


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)