Modulation of Inflammation by Extracellular Granzyme A
van Daalen, Kim R.
Reijneveld, Josephine F.
Frontiers in Immunology
Frontiers Media S.A.
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van Daalen, K. R., Reijneveld, J. F., & Bovenschen, N. (2020). Modulation of Inflammation by Extracellular Granzyme A. Frontiers in Immunology, 11 https://doi.org/10.3389/fimmu.2020.00931
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current literature, accumulating evidence now indicates roles for extracellular GrA in modulating inflammation and inflammatory diseases. This paper aims to explore the literature presenting current knowledge on GrA as an extracellular modulator of inflammation by summarizing (i) the presence and role of extracellular GrA in several inflammatory diseases, and (ii) the potential molecular mechanisms of extracellular GrA in augmenting inflammation.
Immunology, Granzyme A, granzymes, inflammation, extracellular, inflammatory disease
External DOI: https://doi.org/10.3389/fimmu.2020.00931
This record's URL: https://www.repository.cam.ac.uk/handle/1810/306008
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/