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Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Published version
Peer-reviewed

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Authors

Laustsen, Christoffer 
Francis, Susan 
Mendichovszky, Iosif Alexandru 

Abstract

Abstract: Objectives: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Materials and methods: Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Results: Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65–74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. Discussion: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Description

Keywords

Research Article, Biomarker, DWI, ADC, IVIM, DTI

Journal Title

Conference Name

Journal ISSN

0968-5243
1352-8661

Volume Title

Publisher

Springer International Publishing
Sponsorship
European Cooperation in Science and Technology (CA16103)
Medical Research Council UK (MR/R02264X/1)
National Institute of Diabetes and Digestive and Kidney Diseases (1F32DK109591)
H2020 European Research Council (115974)
Deutsche Forschungsgemeinschaft (SFB 1365)
Swiss Re Foundation (IZCOZ0_177140/1, IZCOZ0_177140/1)
Bundesministerium für Forschung und Technologie (VIP 03P00081)