Factors determining human-to-human transmissibility of zoonotic pathogens via contact.
Mather, Alison E
Munster, Vincent J
Müller, Marcel A
Curr Opin Virol
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Richard, M., Knauf, S., Lawrence, P., Mather, A. E., Munster, V. J., Müller, M. A., Smith, D., & et al. (2017). Factors determining human-to-human transmissibility of zoonotic pathogens via contact.. Curr Opin Virol, 22 7-12. https://doi.org/10.1016/j.coviro.2016.11.004
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission. The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens.
Animals, Humans, Bacterial Infections, Zoonoses, Virus Diseases, Parasitic Diseases, Disease Transmission, Infectious
Biotechnology and Biological Sciences Research Council (BB/M014088/1)
European Commission (278976)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (HHSN272201400008C)
External DOI: https://doi.org/10.1016/j.coviro.2016.11.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/306743
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/