The WHO recommends use of mobile phone health technologies (mHealth) to support adherence in HIV [1], [2]. Studies on text messages (SMS) show promise in limited rigorous evaluations[3]. Increasing use of mobile phones in Africa provides an opportunity to use mHealth tools to support resource limited health systems. We used Information-Motivation-Behavioural Skills model of Highly Active Antiretroviral Therapy (HAART or ART) adherence theory of change[4] to locally adapt, implement and evaluate an mHealth tool (Call for Life Uganda – C4LU). The tool is designed to support ART adherence in people living with HIV (PLHIV) in Uganda through interactive voice response (IVR) and SMS. We describe the evolution of the C4LU projects and the interaction of patients with the health tip function of the tool.