Focal Adhesion-Independent Cell Migration.
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Authors
Paluch, Ewa K
Aspalter, Irene M
Sixt, Michael
Publication Date
2016-10-06Journal Title
Annu Rev Cell Dev Biol
ISSN
1081-0706
Publisher
Annual Reviews
Volume
32
Pages
469-490
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Paluch, E. K., Aspalter, I. M., & Sixt, M. (2016). Focal Adhesion-Independent Cell Migration.. Annu Rev Cell Dev Biol, 32 469-490. https://doi.org/10.1146/annurev-cellbio-111315-125341
Abstract
Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration. Together with protrusion extension and cell body retraction, adhesion to the substrate via specific focal adhesion points has long been considered an essential step in cell migration. Although this is true for cells moving on two-dimensional substrates, recent studies have demonstrated that focal adhesions are not required for cells moving in three dimensions, in which confinement is sufficient to maintain a cell in contact with its substrate. Here, we review the investigations that have led to challenging the requirement of specific adhesions for migration, discuss the physical mechanisms proposed for cell body translocation during focal adhesion-independent migration, and highlight the remaining open questions for the future.
Keywords
Focal Adhesions, Animals, Humans, Cell Movement, Models, Biological, Biomechanical Phenomena
Identifiers
External DOI: https://doi.org/10.1146/annurev-cellbio-111315-125341
This record's URL: https://www.repository.cam.ac.uk/handle/1810/307534
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