The Ins and Outs of TAPBPR.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Peptide presentation on MHC class I molecules (MHC-I) is central to mounting effective antiviral and antitumoral immune responses. The tapasin-related protein TAPBPR is an MHC-I peptide editor which shapes the final peptide repertoire displayed on the cell surface. Here, we review recent findings which further elucidate the mechanisms by which TAPBPR performs peptide editing on a molecular level, and how glycosylation on MHC-I influences the interaction with TAPBPR and the peptide loading complex. We also explore how the function of TAPBPR can be utilized to promote exogenous peptide loading directly onto plasma-membrane expressed MHC-I. This has led to the development of new assays to investigate TAPBPR-mediated peptide editing and uncovered translational opportunities of utilizing TAPBPR to treat human disease.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1879-0372
Volume Title
Publisher
Publisher DOI
Sponsorship
Wellcome Trust (109076/Z/15/Z)