Flavin Mononucleotide as a Biomarker of Organ Quality-A Pilot Study.
Pither, Thomas L
Fisher, Andrew J
Dark, John H
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Wang, L., Thompson, E., Bates, L., Pither, T. L., Hosgood, S., Nicholson, M., Watson, C., et al. (2020). Flavin Mononucleotide as a Biomarker of Organ Quality-A Pilot Study.. Transplantation direct, 6 (9), e600. https://doi.org/10.1097/txd.0000000000001046
Among seven transplanted kidneys out of the 11 kidneys that underwent NMP, FMN levels at 60 minutes of NMP were significantly higher in the allografts that developed delayed graft function and primary non-function (p=0.02). 15 livers from 23 circulatory death donors that underwent NRP were deemed suitable for transplantation. Their FMN levels at 30 minutes of NRP were significantly lower than those not procured for transplantation (p=0.004). In contrast, little FMN was released during the 8 lung perfusions. Conclusions: This proof of concept study suggested that FMN in the perfusates of kidney NMP has the potential to predict post-transplant renal function, while FMN at 30 minutes of NRP predicts whether a liver would be accepted for transplantation. 5 More work is required to validate the role of FMN as a putative biomarker to facilitate safe and reliable decision making prior to embarking on transplantation.
Department of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10027)
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External DOI: https://doi.org/10.1097/txd.0000000000001046
This record's URL: https://www.repository.cam.ac.uk/handle/1810/307860
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