Autophagy in Neuronal Development and Plasticity.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
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Authors
Fleming, Angeleen https://orcid.org/0000-0003-3721-7126
Rubinsztein, David C
Abstract
Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease. However, far less is understood about the role of autophagy in other aspects of neuronal physiology. Here we review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal plasticity in adult life and we discuss how these contribute to structural and functional deficits observed in a range of human disorders.
Description
Keywords
autophagy, memory, neurogenesis, neuronal stem cell (NSC), plasticity, psychiatric disease, Autophagy, Humans, Lysosomes, Neurodegenerative Diseases, Neuronal Plasticity, Neurons
Journal Title
Trends Neurosci
Conference Name
Journal ISSN
0166-2236
1878-108X
1878-108X
Volume Title
43
Publisher
Elsevier BV