jats:titleAbstract</jats:title> jats:pThe recent discovery of diffuse dwarf galaxies that are deficient in dark matter appears to challenge the current paradigm of structure formation in our universe. We describe numerical experiments to determine if so-called dark matter deficient galaxies (DMDGs) could be produced when two gas-rich, dwarf-sized galaxies collide with a high relative velocity of ∼300 km sjats:sup−1</jats:sup>. Using idealized high-resolution simulations with both mesh-based and particle-based gravito-hydrodynamics codes, we find that DMDGs can form as high-velocity galaxy collisions and separate dark matter from the warm disk gas, which subsequently is compressed by shock and tidal interaction to form stars. Then using the large simulated universe Iljats:sclustris</jats:sc>TNG, we discover a number of high-velocity galaxy collision events in which DMDGs are expected to form. However, we did not find evidence that these types of collisions actually produced DMDGs in the TNG100-1 run. We argue that the resolution of the numerical experiment is critical to realizing the “collision-induced” DMDG formation scenario. Our results demonstrate one of many routes in which galaxies could form with unconventional dark matter fractions.</jats:p>