Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT
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Peer-reviewed
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Abstract
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.
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Keywords
Chest clinic, 1506, 2313, lung cancer, neutrophil biology, imaging/CT MRI etc
Journal Title
Thorax
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0040-6376
1468-3296
1468-3296
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Publisher
BMJ Publishing Group
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Sponsorship
Wellcome Trust (098351/Z/12/Z)
Medical Research Council (MR/J00345X/1)
National Institute for Health Research (Cambridge Biomedical Research Centre)
Medical Research Council (MR/J00345X/1)
National Institute for Health Research (Cambridge Biomedical Research Centre)