Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform.
Mane, Shivshankar R
Bauer, Dennis M
Angewandte Chemie International Edition
John Wiley & Sons Ltd.
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Beloqui, A., Mane, S. R., Langer, M., Glassner, M., Bauer, D. M., Fruk, L., Barner-Kowollik, C., & et al. (2020). Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform.. Angewandte Chemie International Edition https://doi.org/10.1002/anie.202005747
We introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.
Diels-Alder cycloaddition, bioconjugation, end group, polymer, protein
External DOI: https://doi.org/10.1002/anie.202005747
This record's URL: https://www.repository.cam.ac.uk/handle/1810/310291
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/