Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.
Development (Cambridge, England)
MetadataShow full item record
Watson, C., & Khaled, W. (2020). Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.. Development (Cambridge, England), 147 (22)https://doi.org/10.1242/dev.169862
The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have been gained by the application of recent technological advances in imaging in both real-time and three-dimensions, and in single cell RNA sequencing. These studies have revealed the complexity of subpopulations of cells that contribute to the mammary stem and progenitor cell hierarchy and we suggest a new terminology to distinguish these cells.
Mammary Glands, Human, Mammary Glands, Animal, Epithelial Cells, Stem Cells, Animals, Humans, Mice, Cell Differentiation, Cell Lineage, Embryonic Development, Organogenesis, Female, Embryo, Mammalian
CRUK Career Establishment Award (C47525/A17348)
Cancer Research UK (17348)
Embargo Lift Date
External DOI: https://doi.org/10.1242/dev.169862
This record's URL: https://www.repository.cam.ac.uk/handle/1810/311704
All rights reserved