Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.
Development (Cambridge, England)
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Watson, C., & Khaled, W. (2020). Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.. Development (Cambridge, England), 147 (22)https://doi.org/10.1242/dev.169862
The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have been gained by the application of recent technological advances in imaging in both real-time and three-dimensions, and in single cell RNA sequencing. These studies have revealed the complexity of subpopulations of cells that contribute to the mammary stem and progenitor cell hierarchy and we suggest a new terminology to distinguish these cells.
CRUK Career Establishment Award (C47525/A17348)
Cancer Research UK (17348)
Embargo Lift Date
External DOI: https://doi.org/10.1242/dev.169862
This record's URL: https://www.repository.cam.ac.uk/handle/1810/311704
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