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dc.contributor.authorWatson, Christineen
dc.contributor.authorKhaled, Waliden
dc.date.accessioned2020-10-19T23:31:36Z
dc.date.available2020-10-19T23:31:36Z
dc.date.issued2020-11-15en
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311704
dc.description.abstractThe mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have been gained by the application of recent technological advances in imaging in both real-time and three-dimensions, and in single cell RNA sequencing. These studies have revealed the complexity of subpopulations of cells that contribute to the mammary stem and progenitor cell hierarchy and we suggest a new terminology to distinguish these cells.
dc.description.sponsorshipCRUK Career Establishment Award (C47525/A17348)
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectMammary Glands, Humanen
dc.subjectMammary Glands, Animalen
dc.subjectEpithelial Cellsen
dc.subjectStem Cellsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectCell Differentiationen
dc.subjectCell Lineageen
dc.subjectEmbryonic Developmenten
dc.subjectOrganogenesisen
dc.subjectFemaleen
dc.subjectEmbryo, Mammalianen
dc.titleMammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.en
dc.typeArticle
prism.issueIdentifier22en
prism.publicationDate2020en
prism.publicationNameDevelopment (Cambridge, England)en
prism.volume147en
dc.identifier.doi10.17863/CAM.58794
dcterms.dateAccepted2020-09-23en
rioxxterms.versionofrecord10.1242/dev.169862en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-11-15en
dc.contributor.orcidWatson, Christine [0000-0002-8548-5902]
dc.contributor.orcidKhaled, Walid [0000-0001-9068-5776]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (17348)
pubs.funder-project-idMRC (MR/J001023/1)
pubs.funder-project-idMRC (MR/N022963/1)
cam.orpheus.successMon Nov 23 07:31:02 GMT 2020 - Embargo updated*
cam.orpheus.counter8*
rioxxterms.freetoread.startdate2021-11-15


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